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Fig. 8 | Cell Division

Fig. 8

From: STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cells

Fig. 8

STEAP4 and 50 μM Copper co-treatment downregulates indicated cell cycle genes in Hep G2 cells. A STEAP4 with copper reductase activity reduces PLK1, CDK1, CDC20, CDC25C, and CCNB2 mRNA expression in Hep G2 cells. This synergistic effect is abolished by STEAP4 knockdown via siRNA. * p < 0.05, ** p < 0.01. B STEAP4 with copper reductase activity reduces PLK1, CDK1, CDC20, CDC25C, and CCNB2 protein expression in Hep G2 cells as indicated by representative western blot results

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Cell Division

ISSN: 1747-1028

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