Fig. 11

Schematic diagram of proposed mechanism of STEAP4-mediated copper reductase activity in HCC tumorigenesis suppression via cell cycle regulation. This schematic illustrates STEAP4's functional impact on HCC cells in vitro. STEAP4-mediated copper reduction leads to downregulation of key cell cycle genes, inhibiting G2/M progression in HCC cells. Further investigation into the underlying mechanisms of STEAP4-mediated regulation of cell cycle genes is warranted. (Figure created with Figdraw)