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Fig. 7 | Cell Division

Fig. 7

From: METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma

Fig. 7

LAMA4 induced COL4A1 expression.A Venn diagram of LAMA4 interacting proteins was analyzed by Genemania, STRING and Coexpedia databases. B COL4A1 expression with 371 HCC tumor tissues and 50 normal tissues from TCGA database. C Protein expression of COL4A1 in HCC normal samples (Normal, n = 165) and tumor samples (Primary tumor, n = 165) from CPTAC database. D COL4A1 expression with 374 cancer and 50 normal samples in HCC from ENCORI database. E COL4A1 mRNA expression in tumor tissues (n = 369) and normal tissues (n = 160) of HCC samples from GEPIA database. F Correlation analysis of LAMA4 and COL4A1 in 374 samples from ENCORI database. G Western blot analysis of LAMA interference efficiency in Hep3B/DDP and Huh- 7/DDP cells after transfection with si-LAMA4. H The protein expression level of COL4A1 after interference with LAMA4 in Hep3B/DDP and Huh- 7/DDP cells. I Co-IP assay of LAMA4 and COL4A1 in Hep3B/DDP and Huh- 7/DDP cells. *P < 0.05

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Cell Division

ISSN: 1747-1028

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