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Fig. 4 | Cell Division

Fig. 4

From: METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma

Fig. 4

METTL16 mediated m6A methylation of LAMA4.A The SRAMP website predicted the presence of m6A methylation modification sites in LAMA4. B The expression correlation between METTL16 and LAMA4 was analyzed in 374 HCC samples from ENCORI database. C RIP assay of LAMA4 and METTL16 in Hep3B/DDP and Huh- 7/DDP cells. D, E The m6A methylation level of LAMA4 in Hep3B/DDP and Huh- 7/DDP cells after METTL16 knockdown was determined by MeRIP. F, G After silencing METTL16, mRNA expression levels of LAMA4 after treatment with Act D at 0 h, 3 h, 6 h and 9 h in Hep3B/DDP and Huh- 7/DDP cells. *P < 0.05

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Cell Division

ISSN: 1747-1028

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