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Fig. 3 | Cell Division

Fig. 3

From: METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma

Fig. 3

METTL16 increased LAMA4 expression.A Heat map of gene expression profile in Huh- 7 after METTL16 knockdown from GSE224008. B qRT-PCR assay for LAMA4 with si-METTL16 in Hep3B/DDP and Huh- 7/DDP cells. C Western blot assay for LAMA4 after transfection of si-METTL16 in Hep3B/DDP and Huh- 7/DDP cells. D LAMA4 expression with 371 HCC tumor tissues and 50 normal tissues from TCGA database. E Protein expression of LAMA4 in HCC normal samples (Normal, n = 165) and tumor samples (Primary tumor, n = 165) from CPTAC database. F LAMA4 expression with 374 cancer and 50 normal samples in HCC from ENCORI database. G LAMA4 mRNA expression in tumor tissues (n = 369) and normal tissues (n = 160) of HCC samples by GEPIA database. H mRNA expression of LAMA4 in sensitive tissues (n = 29) and resistant tissues (n = 33). I Correlation assay of METTL16 and LAMA4. J Protein expression of LAMA4 in THLE- 2, Hep3B, Hep3B/DDP, Huh- 7 and Huh- 7/DDP cells. *P < 0.05

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Cell Division

ISSN: 1747-1028

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