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Fig. 2 | Cell Division

Fig. 2

From: METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma

Fig. 2

METTL16 facilitated progress and resistance of HCC resistant cells.A The interference efficiency of si-METTL16 in Hep3B/DDP, and Huh- 7/DDP cells were measured by western blot. B IC50 values of Hep3B/DDP and Huh- 7/DDP cells after interference of METTL16. C, D The expression of MDR1 and MRP1 in Hep3B/DDP and Huh- 7/DDP cells with si-METTL16 was analyzed by western blot. E MTT assay of cell viability in Hep3B/DDP and Huh- 7/DDP cells after interference of METTL16. F EdU staining of Hep3B/DDP and Huh- 7/DDP cells after interference of METTL16: EdU (red) staining, nucleus (blue) staining. G Flow cytometry assay of apoptosis in Hep3B/DDP and Huh- 7/DDP cells after interference of METTL16. H, I Transwell assay was used for cell invasion in Hep3B/DDP and Huh- 7/DDP cells after interference of METTL16. J Cell migration of cells was detected by wound healing in Hep3B/DDP and Huh- 7/DDP cells after interference of METTL16. *P < 0.05

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Cell Division

ISSN: 1747-1028

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