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Fig. 6 | Cell Division

Fig. 6

From: Maraviroc enhances Bortezomib sensitivity in multiple myeloma by inhibiting M2 macrophage polarization via PI3K/AKT/RhoA signaling pathway in macrophages

Fig. 6

CCL3-CCR5 axis blockade prevents M2 macrophage polarization and MM progression in vivo. A: Tumor volumes in mice injected with no cells (Normal), CCL3-NC RPMI 8226 cells, CCL3-OE RPMI 8226 cells, or shCCL3 cells. B: Quantification of the results from panel A. C: Tumor volumes in mice injected with CCL3-OE cells and then treated with MVC, Bor or Bor combined with MVC 24 h. D: Quantification of the results from panel C. E-H: Representative images and quantification of the CD206 + macrophage content in xenograft NOD/SCID mouse model tumor tissues by the IHC staining (×40)

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Cell Division

ISSN: 1747-1028

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