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Fig. 2 | Cell Division

Fig. 2

From: Maraviroc enhances Bortezomib sensitivity in multiple myeloma by inhibiting M2 macrophage polarization via PI3K/AKT/RhoA signaling pathway in macrophages

Fig. 2

MM cells promote macrophages towards M2 polarization via autocrine CCL3. A-B: Expression levels of CCL3 and CCR5 mRNA in monocytic THP-1 and MM RPMI 8226 and MM IM9 cell lines was evaluated by qRT-PCR. C: Verification of overexpression (CCL3 OE) and knockdown (shCCL3) RPMI 8226 cells by qRT-PCR. D: Flow cytometric analysis of CD206 + cells after co-culture of THP-1 cells with CCL3-NC RPMI 8226 cells, RPMI 8226 cells, CCL3-OE RPMI 8226 cells or shCCL3 RPMI 8226 cells. E: Quantification of the differences in CD206 + cell levels among groups

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Cell Division

ISSN: 1747-1028

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