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Fig. 1 | Cell Division

Fig. 1

From: PP2A-Tws dephosphorylates Map205, is required for Polo localization to microtubules and promotes cytokinesis in Drosophila

Fig. 1

Regulation of Polo localization and function during mitosis and cytokinesis. (A) The dynamic localization of Polo during the cell cycle. During mitosis (right), Polo (green) is strongly localized to kinetochores and centrosomes. During cytokinesis and interphase (left), Polo is strongly localized to microtubules. (B) Molecular regulation of Polo. During mitosis interphase (left), Polo interacts with Map205 on microtubules. This interaction stabilizes the PBD (blue) of Polo in a conformation that binds and inhibits the KD (green). During mitosis (right), mitotic Cyclin-CDK phosphorylation of Map205 causes the release of Polo. The phosphorylation of Polo interactors (X) facilitates their interactions with the PBD targeting Polo at centrosomes, kinetochores (KT) and the midbody core. During mitotic exit, Map205 dephosphorylation by PP2A-Tws promotes the recruitment of Polo by Map205 on microtubules

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Cell Division

ISSN: 1747-1028

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