Fig. 6
From: Curcumin enhances ATG3-dependent autophagy and inhibits metastasis in cervical carcinoma
Schematic representation of curcumin’s dual role in inhibiting metastasis and enhancing autophagy in cervical cancer. Curcumin reduces pericyte detachment and recruitment, thereby decreasing angiogenesis and metastatic potential through the downregulation of PDGFRβ signaling. Additionally, curcumin enhances autophagy by modulating key proteins ATG3 and LC3, impacting the PI3K/AKT and MAPK/ERK pathways. These mechanisms highlight curcumin’s potential as a therapeutic agent in targeting both tumor growth and metastasis in cervical cancer, emphasizing its multifaceted approach to cancer treatment. Created with BioRender.com