Fig. 2

Curcumin and ATG3 Knockdown Inhibit Migration and Proliferation of Cervical Cancer Cells. (A) Wound healing assay images of SiHa cells treated with control, ShATG3, curcumin, and ShATG3 combined with curcumin at 0, 24, and 48 h. The yellow lines indicate the wound edges. (B) Quantification of wound closure in Siha cells at 24 and 48 h. Wound closure percentage was significantly reduced in the ShATG3, curcumin, and ShATG3 + curcumin groups compared to the control group. (C) Wound healing assay images of HeLa cells treated with control, ShATG3, curcumin, and ShATG3 combined with curcumin at 0, 24, and 48 h. The yellow lines indicate the wound edges. (D) Quantification of wound closure in HeLa cells at 24 and 48 h. Wound closure percentage was significantly reduced in the ShATG3, curcumin, and ShATG3 + curcumin groups compared to the control group. (E) CCK-8 assays demonstrating reduced cell proliferation in both SiHa (left) and HeLa (right) cells following the combined treatment. Statistical significance is indicated by **P < 0.01, ***P < 0.001, ****P < 0.0001