Fig. 1

RNF6 was high expressed in CC and correlated with poor prognosis in patients. (A) Comparisons of RNF6 expression levels between various tumor tissues and their corresponding normal tissues using TCGA data from the TIMER database. (B) RNF6 mRNA expression in cervical cancer (CC) tissues compared with normal cervical epithelial tissue according to the GEPIA database. (C, D) Prognostic associations, encompassing overall survival (OS) and disease-free survival (DFS), among CC patients using GEPIA database. (E, F) Prognostic associations, including OS and recurrence-free survival (RFS), in CC patients according to the KM-Plotter database. (G) Representative immunohistochemistry (IHC) staining images showing RNF6 protein expression in human CC tissues compared to adjacent cervical epithelial tissue. (H) Statistical results of IHC scoring presented with a box plot. (I, J) Comparison of patients with higher RNF6 expression levels (n = 63) to those with lower RNF6 expression (n = 86) using Kaplan-Meier survival analysis, comprising OS and progression-free survival (PFS). *p < 0.05; **p < 0.01