Fig. 6
From: NPRL2 is required for proliferation of oncogenic Ras-transformed bronchial epithelial cells
NPRL2 depletion suppresses HSE- and ARE-directed luciferase reporter activities. Ras-AI-T2 cells that were stably transfected with the NRF2/ARE- (A) or HSF1/HSE- (B) luciferase reporters were transduced with control shRNA virions (pLKO.1) or depleted of NPRL2 (shNPRL2). At the indicated times, cells were collected and assayed for luciferase activities. Treatment of the control virion-transduced cells with ATO (5 μM for 6 h) was used as a positive control for both reporters. Results are mean ± SD as determined from three independent experiments. **p < 0.01 and ***p < 0.001 by Student’s t-test