Table 1 Effect of SIRT3 on autophagy in several diseases
From: Advances in SIRT3 involvement in regulating autophagy-related mechanisms
The experimental subject | Effect of SIRT3 on autophagy factors | References |
|---|---|---|
6 weeks SD male rats (OA model) | Enhanced expression levels of SIRT3, increased the expression of LC3B, Beclin − 1. | [26] |
A549 cells (DOX) | Enhanced expression levels of SIRT3, increased the expression of LC3 and decreased the expression of p62. | [27] |
10 weeks C57BL/6 male rats | Knockdown of SIRT3 resulted in decreased expression levels of LC3-II and Beclin-1. | [28] |
SD rat (OGD model) | Enhanced expression levels of SIRT3, increased the expression of LC3-II and Beclin-1. | [29] |
SH-SY5Y cells (PD model) | Enhanced expression levels of SIRT3 increased the expression of LC3- II, and Beclin − 1. | [30] |
129S1/SvlmJ mice (cardiac hypertrophy model) | Knockdown of SIRT3 expression levels, decreased the LC3- II, and Beclin − 1 expression, and increased p62 expression. | [31] |
SH-SY5Y cells (PD model) | Inhibition of SIRT3 expression levels increased p62 expression. | [32] |
10 weeks C57BL/6 mice (IRI model) | Knockdown of SIRT3 resulted in decreased expression levels of LC3-II and Beclin-1. | [33] |
HK-2 cells (HG) | Enhanced expression of SIRT3, increased the expression of LC3- II and Beclin − 1 and decreased the expression of p62. | [34] |