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Fig. 2 | Cell Division

Fig. 2

From: Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia

Fig. 2

Overexpression of Klotho reversed the regulating effects of hypoxia on cell viability, apoptosis, invasion and senescence. A, B The human trophoblasts were subjected to hypoxia, and cell viability was determined by performing MTT assay. C The Annexin V-FITC/PI double staining method was employed to detect cell apoptosis of human trophoblasts. D Cell invasion abilities of HTR-8/SVneo and TEV cells were determined by performing Transwell assay. E Western Blot analysis was used to analyze the expression status of the cellular senescence-related proteins (p16 and p21) in human trophoblasts. Each experiment was repeated at least for three times, and *P < 0.05 was considered as statistical significance. Each experiment was repeated at least for three times

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Cell Division

ISSN: 1747-1028

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