Fig. 8
Graphical illustration of the three modes of cell proliferation, mitosis, abnormal mitosis, and non-mitosis. A Cellular behaviors under the three modes of proliferation. Purple: Mitosis; Pink: Abnormal mitosis; Green: Non-mitosis; B Reversable transitions, indicated by two-headed arrows, from mitosis, abnormal mitosis to non-mitosis or vice versa, under varying dosages of anti-cancer drugs. This hypothetical reversible transition may also apply to other stressful microenvironmental conditions, such as acidic environment