Fig. 5

Degradation of substrate proteins by the adenoviral proteins E1B55K and E4orf6. The adenoviral protein E1B55K recognizes substrates to be polyubiquitinated, and also interacts with another adenoviral protein, E4orf6. E4orf6 further interacts with the Elongin B/C heterodimer, Cul5, and Rbx1, E2, and ubiquitin (Ub)