Figure 9

Silencing of Smurf2 leads to G0/G1 phase arrest. Cell cycle distribution of (A) MDA-MB-231 cells and (B) MCF-7 cells treated with Smurf2 siRNA and control siRNA were accessed by flow cytometry at 24, 48, and 72 hours post-transfection. Results are representative histogram of three independent experiments, plotting cell count vs. DNA content.