Figure 7

Speculative model of a putative pathway induced by DNMT1 depletion. Schematic shows the effects of DNMT1 depletion perceived by a "sensor" factor (p14ARF) that activates a pathway p53-controlled triggering G1 arrest in normal cells. If p53 or p14ARF are absent or not working properly, cells are unable to sense DNMT1 depletion and, thus, progress in the cell cycle incorrectly with wrong DNA methylation patterns triggering aneuploidy.